PI: Tiangang Li, PhD
Co-I: Jed Friedman, PhD
Department of Physiology
Funding Organization: National Institutes of Health (NIH)/ National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant Type: R01
Title of Grant: Novel Roles of Cullin-RING E3 Ligases in Liver Pathophysiology
Dates: 02/16/23 – 01/31/27
Anticipated Cumulative Amount Awarded: $1,571,476*
*Research made possible through this grant is supported by the National Institute of Diabetes and Digestive and Kidney Diseases, a component of the National Institutes of Health, under the award number R01DK134316.
PI: Jeanie Tryggestad, MD
Department of Pediatrics
Funding Organization: National Institutes of Health (NIH)/ National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant Type: U01
Title of Grant: Identifying Metabolic and Psychosocial Antecedents and Characteristics of youth-onset Type 2 diabetes (IMPACT DM)
Dates: 02/23/23 – 01/31/29
Anticipated Cumulative Amount Awarded: $3,151,228*
*Research made possible through this grant is supported by the National Institute of Diabetes and Digestive and Kidney Diseases, a component of the National Institutes of Health, under the award number U01DK135007.
PI: Archana Unnikrishnan, PhD
Department of Biochemistry & Molecular Biology
Funding Organization: Oklahoma Center for Adult Stem Cell Research (OCASCR)
Grant Type: Research
Title of Grant: Characterization of the molecular heterogeneity of the Intestinal Stem Cells
Dates: 07/01/23 – 06/30/24
Amount Awarded: $149,780
PI: Marisol Castillo-Castrejon, PhD
Department of Pathology
Funding Organization: Center for Advancement of Science & Technology (OCAST)
Grant Type: HR23
Title of Grant: Reduced B cell Estrogen Signaling Contributes to Menopause-associated Weight Gain
Dates: 04/01/2023 – 3/31/2026
Anticipated Cumulative Amount Awarded: $135,000
PI: Mary Beth Humphrey, MD, PhD, FACP
Department of Internal Medicine
Funding Organization: Presbyterian Health Foundation (PHF)
Grant Type: Team Science
Title of Grant: Gut Microbiome and bone remodeling
Dates: 07/03/2023 – 07/02/2024
Amount Awarded: $100,000
PI: Dean Myers, PhD
Department of Physiology
Funding Organization: Presbyterian Health Foundation (PHF)
Grant Type: Team Science
Title of Grant: Development of a Baboon (Papio anubis) Model of Western Diet and Paternal Obesity – Mechanisms for Fetal/Offspring Epigenetic Programming of Metabolic Disorders
Dates: 07/03/2023 – 07/02/2024
Amount Awarded: $100,000
PI: Michael Rudolph, PhD
Department of Physiology
Funding Organization: Presbyterian Health Foundation (PHF)
Grant Type: Team Science (year 3)
Title of Grant: Maternal Exercise Induces Milk Thermogenic Brown Adipose Tissue Activators that Stimulate Infant Metabolism
Dates: 07/03/2023 – 07/02/2024
Amount Awarded: $100,000
PI: Kathryn Burge, PhD
Department of Pediatrics
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Novel Pilot Project – Year 1
Title of Grant: Microbiota-derived tryptophan metabolites and intestinal tuft cell signaling in vertical transmission of maternal metabolic phenotype
Dates: 07/01/23 – 06/30/24
Amount Awarded: $70,000
PI: John R. Clegg, PhD
Stephenson School of Biomedical Engineering
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Novel Pilot Project – Year 1
Title of Grant: Maternal Macrophage Immunotherapy: A Novel Strategy to Prevent Developmental Programming of Metabolic Disease in Obese Pregnancy
Dates: 07/01/23 – 06/30/24
Amount Awarded: $70,000
PI: Sirish Palle, MD
Department of Pediatrics
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Novel Pilot Project – Year 1
Title of Grant: Metabolomic profiling for pediatric NAFLD
Dates: 07/01/23 – 06/30/24
Amount Awarded: $60,457
PI: Amanda Sharpe, PhD
Department of Pharmaceutical Sciences
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Novel Pilot Project – Year 1
Title of Grant: The role of melanocortin-4 receptors on astrocytes in the hypothalamus on inflammaging, adipocity, and weight regulation
Dates: 07/01/23 – 06/30/24
Amount Awarded: $70,000
PI: Kevin Short, PhD, FACSM
Department of Pediatrics
Co-I: Jed Friedman, PhD
Department of Physiology
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Novel Pilot Project – Year 1
Title of Grant: Maternal obesity and diet: Impact on liver and metabolic health during pregnancy and post-partum
Dates: 07/01/23 – 06/30/24
Amount Awarded: $70,000
PI: David Sparling, MD, PhD
Department of Pediatrics
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Novel Pilot Project – Year 1
Title of Grant: Changes in CRISPLD2 Secretion During Progression of Type 2 Diabetes Mellitus
Dates: 07/01/23 – 06/30/24
Amount Awarded: $63,000
PI: Jian Xu, PhD
Department of Physiology
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Novel Pilot Project – Year 1
Title of Grant: Endothelial Cell-derived FGF21 and Pancreatic β-Cell Survival in Diabetes
Dates: 07/01/23 – 06/30/24
Amount Awarded: $70,000
PI: Nisha Thomas, PhD
Stephenson Cancer Center
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Novel Pilot Project for Post-Docs – Year 1
Title of Grant: Estrogen Receptor Inhibition Links Unhealthy Adipose Tissue to Diabetes After Breast Cancer
Dates: 07/01/23 – 06/30/24
Amount Awarded: $70,000
PI: Joni Beck, PharmD, BC-ADM, CDE
Department of Pediatrics
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Team Science – Year 1
Title of Grant: Wavelengths-Transitioning for Adolescents to Young Adult with Diabetes
Dates: 07/01/23 – 06/30/24
Amount Awarded: $100,000
PI: Marisol Castillo-Castrejon, PhD
Department of Pathology
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Team Science – Year 1
Title of Grant: Contribution of B cells to obesity and menopause-associated diabetes risk
Dates: 07/01/23 – 06/30/24
Amount Awarded: $100,000
PI: Mary Beth Humphrey, MD, PhD, FACP
Department of Internal Medicine
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Team Science
Title of Grant: Exploring the role of Trem2+ kidney resident macrophages in diabetic kidney disease
Dates: 07/01/23 – 06/30/24
Amount Awarded: $100,000
PI: Stephanie Pierce, MD
Department of Obstetrics and Gynecology
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Team Science – Year 2 addendum
Title of Grant: Pilot RCT Intervention Targeting Elevated Triglycerides with a Point-of-Care Meter and Omega-3 Fatty Acid to Normalize Triglycerides and Fetal Growth
Dates: 07/01/23 – 06/30/24
Amount Awarded: $289,532
PI: Jeanie Tryggestad, MD
Department of Pediatrics
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Team Science – Year 1
Title of Grant: Metabolic And Glycemic Indices in Children with youth-onset type 2 Diabetes Mellitus (MAGIC DM)
Dates: 07/01/23 – 06/30/24
Amount Awarded: $100,000
PI: Sangpil Yoon, PhD
School of Electrical and Computer Engineering
Funding Organization: Harold Hamm Diabetes Center (HHDC)
Grant Type: Team Science – Year 1
Title of Grant: Multiplexed imaging of immune cells after islet and beta cell transplantation
Dates: 07/01/23 – 06/30/24
Amount Awarded: $99,908
PI: Kamiya Mehla, PhD
Department of Oncology Science
Funding Organization: Harold Hamm Diabetes Center (HHDC)/ Stephenson Cancer Center (SCC)
Grant Type: HHDC-SCC Team Science – Year 1
Title of Grant: Pancreatic Cancer and Hyperlipidemia
Dates: 07/01/23 – 06/30/24
Amount Awarded: $100,000
PI: Elizabeth Wellberg, PhD
Department of Pathology
Funding Organization: Harold Hamm Diabetes Center (HHDC)/ Stephenson Cancer Center (SCC)
Grant Type: HHDC-SCC Team Science – Year 1
Title of Grant: Characterization of the influence of obesity on the in-situ-to-invasive transition of breast cancer
Dates: 07/01/23 – 06/30/24
Amount Awarded: $100,000
Recipient: Rahul Rajala, Doctoral Candidate
Griffin Laboratory: Cardiovascular Biology (OMRF)
Funding Organization: American Heart Association (AHA)
Grant Type: AHA Predoctoral Fellowship
Title of Grant: The Role of Endothelial Protease-Activated Receptors in Modulating Insulin Signaling
Dates: 2022 – 2024
Amount Awarded: $65,106
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