Grant Recipients

New Grants to Harold Hamm Diabetes Center Members

NIH/NIDDK R01 GRANT (02/2023 – 01/2027)

PI: Tiangang Li, PhD
Co-I: Jed Friedman, PhD

Department of Physiology

Funding Organization: National Institutes of Health (NIH)/ National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Grant Type: R01

Title of Grant: Novel Roles of Cullin-RING E3 Ligases in Liver Pathophysiology

Dates: 02/16/23 – 01/31/27

Anticipated Cumulative Amount Awarded: $1,571,476*

*Research made possible through this grant is supported by the National Institute of Diabetes and Digestive and Kidney Diseases, a component of the National Institutes of Health, under the award number R01DK134316.


NIH/NIDDK U01 GRANT (02/2023 – 01/2029)

PI: Jeanie Tryggestad, MD
Department of Pediatrics

Funding Organization: National Institutes of Health (NIH)/ National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Grant Type: U01

Title of Grant: Identifying Metabolic and Psychosocial Antecedents and Characteristics of youth-onset Type 2 diabetes (IMPACT DM)

Dates: 02/23/23 – 01/31/29

Anticipated Cumulative Amount Awarded: $3,151,228*

*Research made possible through this grant is supported by the National Institute of Diabetes and Digestive and Kidney Diseases, a component of the National Institutes of Health, under the award number U01DK135007.


OCASCR GRANT (07/2023 – 06/2024)

PI: Archana Unnikrishnan, PhD
Department of Biochemistry & Molecular Biology

Funding Organization: Oklahoma Center for Adult Stem Cell Research (OCASCR)

Grant Type: Research

Title of Grant: Characterization of the molecular heterogeneity of the Intestinal Stem Cells

Dates: 07/01/23 – 06/30/24

Amount Awarded: $149,780


OCAST GRANT (04/2023 – 3/31/2026)

PI: Marisol Castillo-Castrejon, PhD
Department of Pathology

Funding Organization: Center for Advancement of Science & Technology (OCAST)

Grant Type: HR23

Title of Grant: Reduced B cell Estrogen Signaling Contributes to Menopause-associated Weight Gain

Dates: 04/01/2023 – 3/31/2026

Anticipated Cumulative Amount Awarded: $135,000


PHF Team Science GRANTS

PI: Mary Beth Humphrey, MD, PhD, FACP
Department of Internal Medicine

Funding Organization: Presbyterian Health Foundation (PHF)

Grant Type: Team Science

Title of Grant: Gut Microbiome and bone remodeling

Dates: 07/03/2023 – 07/02/2024

Amount Awarded: $100,000

PI: Dean Myers, PhD
Department of Physiology

Funding Organization: Presbyterian Health Foundation (PHF)

Grant Type: Team Science

Title of Grant: Development of a Baboon (Papio anubis) Model of Western Diet and Paternal Obesity – Mechanisms for Fetal/Offspring Epigenetic Programming of Metabolic Disorders

Dates: 07/03/2023 – 07/02/2024

Amount Awarded: $100,000

PI: Michael Rudolph, PhD
Department of Physiology

Funding Organization: Presbyterian Health Foundation (PHF)

Grant Type: Team Science (year 3)

Title of Grant: Maternal Exercise Induces Milk Thermogenic Brown Adipose Tissue Activators that Stimulate Infant Metabolism

Dates: 07/03/2023 – 07/02/2024

Amount Awarded: $100,000


HHDC NOVEL PILOT PROJECT GRANTS

PI: Kathryn Burge, PhD
Department of Pediatrics

Funding Organization: Harold Hamm Diabetes Center (HHDC)

Grant Type: Novel Pilot Project – Year 1

Title of Grant: Microbiota-derived tryptophan metabolites and intestinal tuft cell signaling in vertical transmission of maternal metabolic phenotype

Dates: 07/01/23 – 06/30/24

Amount Awarded: $70,000

PI: John R. Clegg, PhD
Stephenson School of Biomedical Engineering

Funding Organization: Harold Hamm Diabetes Center (HHDC)

Grant Type: Novel Pilot Project – Year 1

Title of Grant: Maternal Macrophage Immunotherapy: A Novel Strategy to Prevent Developmental Programming of Metabolic Disease in Obese Pregnancy

Dates: 07/01/23 – 06/30/24

Amount Awarded: $70,000

PI: Sirish Palle, MD
Department of Pediatrics

Funding Organization: Harold Hamm Diabetes Center (HHDC)

Grant Type: Novel Pilot Project – Year 1

Title of Grant: Metabolomic profiling for pediatric NAFLD

Dates: 07/01/23 – 06/30/24

Amount Awarded: $60,457

PI: Amanda Sharpe, PhD
Department of Pharmaceutical Sciences

Funding Organization: Harold Hamm Diabetes Center (HHDC)

Grant Type: Novel Pilot Project – Year 1

Title of Grant: The role of melanocortin-4 receptors on astrocytes in the hypothalamus on inflammaging, adipocity, and weight regulation

Dates: 07/01/23 – 06/30/24

Amount Awarded: $70,000

PI: Kevin Short, PhD, FACSM
Department of Pediatrics

Co-I: Jed Friedman, PhD
Department of Physiology

Funding Organization: Harold Hamm Diabetes Center (HHDC)

Grant Type: Novel Pilot Project – Year 1

Title of Grant: Maternal obesity and diet: Impact on liver and metabolic health during pregnancy and post-partum

Dates: 07/01/23 – 06/30/24

Amount Awarded: $70,000

PI: David Sparling, MD, PhD
Department of Pediatrics

Funding Organization: Harold Hamm Diabetes Center (HHDC)

Grant Type: Novel Pilot Project – Year 1

Title of Grant: Changes in CRISPLD2 Secretion During Progression of Type 2 Diabetes Mellitus

Dates: 07/01/23 – 06/30/24

Amount Awarded: $63,000

PI: Jian Xu, PhD
Department of Physiology

Funding Organization: Harold Hamm Diabetes Center (HHDC)

Grant Type: Novel Pilot Project – Year 1

Title of Grant: Endothelial Cell-derived FGF21 and Pancreatic β-Cell Survival in Diabetes

Dates: 07/01/23 – 06/30/24

Amount Awarded: $70,000


HHDC NOVEL PILOT PROJECT FOR POSTDOCS GRANT (07/2023 – 06/2024)

PI: Nisha Thomas, PhD
Stephenson Cancer Center

Funding Organization: Harold Hamm Diabetes Center (HHDC)

Grant Type: Novel Pilot Project for Post-Docs – Year 1

Title of Grant: Estrogen Receptor Inhibition Links Unhealthy Adipose Tissue to Diabetes After Breast Cancer

Dates: 07/01/23 – 06/30/24

Amount Awarded: $70,000


HHDC TEAM SCIENCE GRANTS

PI: Joni Beck, PharmD, BC-ADM, CDE
Department of Pediatrics

Funding Organization: Harold Hamm Diabetes Center (HHDC)

Grant Type: Team Science – Year 1

Title of Grant: Wavelengths-Transitioning for Adolescents to Young Adult with Diabetes

Dates: 07/01/23 – 06/30/24

Amount Awarded: $100,000

PI: Marisol Castillo-Castrejon, PhD
Department of Pathology

Funding Organization: Harold Hamm Diabetes Center (HHDC)

Grant Type: Team Science – Year 1

Title of Grant: Contribution of B cells to obesity and menopause-associated diabetes risk

Dates: 07/01/23 – 06/30/24

Amount Awarded: $100,000

PI: Mary Beth Humphrey, MD, PhD, FACP
Department of Internal Medicine

Funding Organization: Harold Hamm Diabetes Center (HHDC)

Grant Type: Team Science

Title of Grant: Exploring the role of Trem2+ kidney resident macrophages in diabetic kidney disease

Dates: 07/01/23 – 06/30/24

Amount Awarded: $100,000

PI: Stephanie Pierce, MD
Department of Obstetrics and Gynecology

Funding Organization: Harold Hamm Diabetes Center (HHDC)

Grant Type: Team Science – Year 2 addendum

Title of Grant: Pilot RCT Intervention Targeting Elevated Triglycerides with a Point-of-Care Meter and Omega-3 Fatty Acid to Normalize Triglycerides and Fetal Growth

Dates: 07/01/23 – 06/30/24

Amount Awarded: $289,532

PI: Jeanie Tryggestad, MD
Department of Pediatrics

Funding Organization: Harold Hamm Diabetes Center (HHDC)

Grant Type: Team Science – Year 1

Title of Grant: Metabolic And Glycemic Indices in Children with youth-onset type 2 Diabetes Mellitus (MAGIC DM)

Dates: 07/01/23 – 06/30/24

Amount Awarded: $100,000

PI: Sangpil Yoon, PhD
School of Electrical and Computer Engineering

Funding Organization: Harold Hamm Diabetes Center (HHDC)

Grant Type: Team Science – Year 1

Title of Grant: Multiplexed imaging of immune cells after islet and beta cell transplantation

Dates: 07/01/23 – 06/30/24

Amount Awarded: $99,908


HHDC-SCC TEAM SCIENCE GRANTS

PI: Kamiya Mehla, PhD
Department of Oncology Science

Funding Organization: Harold Hamm Diabetes Center (HHDC)/ Stephenson Cancer Center (SCC)

Grant Type: HHDC-SCC Team Science – Year 1

Title of Grant: Pancreatic Cancer and Hyperlipidemia

Dates: 07/01/23 – 06/30/24

Amount Awarded: $100,000

PI: Elizabeth Wellberg, PhD
Department of Pathology

Funding Organization: Harold Hamm Diabetes Center (HHDC)/ Stephenson Cancer Center (SCC)

Grant Type: HHDC-SCC Team Science – Year 1

Title of Grant: Characterization of the influence of obesity on the in-situ-to-invasive transition of breast cancer

Dates: 07/01/23 – 06/30/24

Amount Awarded: $100,000


American Heart Association Grant

Recipient: Rahul Rajala, Doctoral Candidate
Griffin Laboratory: Cardiovascular Biology (OMRF)

Funding Organization: American Heart Association (AHA)

Grant Type: AHA Predoctoral Fellowship

Title of Grant: The Role of Endothelial Protease-Activated Receptors in Modulating Insulin Signaling

Dates: 2022 – 2024

Amount Awarded: $65,106

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