Core 2: Biospecimen, Metabolomics, and Pathology Core

Core Co-Directors: Ian S. Hagemann, M.D., PhD, Mark A. Watson, M.D., PhD, and Gary J. Patti, M.D., PhD

The goals of the Biospecimen, Metabolomics, and Pathology (BMP) Core are to provide high-quality, clinically annotated biospecimens, pathology expertise, and metabolomics and spatial profiling analysis platforms to all three projects and future Developmental Research Program and Career Enhancement Program projects in the Route 66 Endometrial Cancer SPORE, and to serve as a resource to the broader endometrial cancer research community. The BMP Core is structured as a federated biospecimen resource spanning the three institutions: Washington University in St. Louis, University of New Mexico, and University of Oklahoma. The biospecimen storage and distribution component of the BMP Core leverages the extensive infrastructure of the three existing institutional Cancer Center biobanks with over 40 years of combined experience.

Specific Aim 1: Support biospecimen collection, processing, annotation, and quality review and providemetabolomic and spatial profiling analyses for all projects in the Route 66 Endometrial Cancer SPORE.

Specific Aim 2: Provide a high-quality, clinically annotated resource of endometrial cancer biospecimens for translational research projects both within and external to the SPORE.

Resources related to the BMP Core:

• Gynecologic Oncology Tissue Bank
• Tissue Procurement Core – SCC
• Center for Proteomics, Metabolomics, and Isotope Tracing
• OUHSC Tissue Pathology & Biospecimen
• UNM Human Tissue Repository

Organizational structure of the BMP Core. HTR-TASR, Human Tissue Repository and Tissue Analysis Shared Resource; OUHSC, University of Oklahoma Health Sciences Center; PDX, patient-derived xenograft; SCC, Siteman Cancer Center; TMAs, tissue microarrays; TPSR, Tissue Pathology Shared Resource; UNM, University of New Mexico; WUSTL, Washington University in St. Louis.